Selective testosterone propionate side effects imidazoline receptor agonists responsible for the tonic and reflex control of the sympathetic nervous system. Slightly communicates with the central alpha2-adrenergic receptors due to the interaction which are mediated by dry mouth and sedation, lowers blood pressure (BP). It reduces the resistance of tissues to insulin.
The impact on hemodynamics: reduction in systolic and diastolic blood pressure with a single and long-term treatment of moxonidine is associated with a decrease in pressor actions of the sympathetic system in the peripheral vessels, a decrease in peripheral vascular resistance, while cardiac output and heart rate (HR) not significantly changed.
: Hypersensitivity to the drug, sick sinus syndrome, sinoatrial and atrioventricular block II and III degree, bradycardia (heart rate less than 50 bpm. / Min.), Chronic heart failure class III and IV (in NYHA classification), angioedema swelling in history, unstable angina, severe liver failure, chronic renal insufficiency (creatinine clearance less than 30 ml / min., creatinine 160 umol / l), age 18 years (effectiveness and safety have not been established), lactation period, simultaneous reception tricyclic antidepressants, galactose intolerance, lactose deficiency or glucose-galactose malabsorption.
Precautions: Parkinson’s disease (severe), epilepsy, glaucoma, depression, “intermittent” claudication, Raynaud’s disease, pregnancy, atrioventricular block I stpeni, chronic renal insufficiency (creatinine clearance of more than 30 but less than 60 ml / min.), Cerebrovascular disease after myocardial infarction, chronic heart failure class I and II expressed liver failure – due to lack of experience in the application, hemodialysis.
Pregnancy and lactation
No clinical data on the negative impact on the course of pregnancy there. However, caution should be exercised by appointing Moksogammu pregnant.
Dosing and Administration
Inside, regardless of meals, drinking plenty of fluids. In most cases Moksogammy initial dose is 0.2 mg per day, in one portion, preferably in the morning. When testosterone propionate side effects insufficient therapeutic effect dose can be increased after 3 weeks of treatment, and 0.4 mg per day for single or 2 divided doses. The maximum daily dose, which should be divided into 2 doses (morning and evening), is 0.6 mg. The maximum single dose is 0.4 mg.
Elderly patients with normal renal function, dosage recommendations are the same as for adult patients.
In patients with renal insufficiency (Kretinina clearance 30-60 ml / min.) And in patients on hemodialysis the single dose should not exceed 0.2 mg, the maximum daily dose of 0.4 mg.
Overdose Symptoms: headache, sedation, somnolence, excessively pronounced decrease in blood pressure, dizziness, weakness, bradycardia, dry mouth, vomiting, fatigue and pain in the stomach.Potentially also possible transient increase in blood pressure, tachycardia, hyperglycemia. Treatment: as a specific antidote is administered idazoxan (antagonist of imidazolines). Gastric lavage (immediately after administration), administration of activated charcoal and laxatives, symptomatic therapy. In the case of reduction of blood pressure is recommended to restore the circulating blood volume due to fluid administration. Bradycardia can be stopped by atropine. Alpha-adrenoceptor antagonists can reduce or eliminate transient hypertension moxonidine in overdose.
Interaction with other drugs
moxonidine may be administered with thiazide diuretics and blockers “slow” calcium channels. In a joint application of moxonidine with these and other antihypertensives mutual strengthening of moxonidine action. In the appointment of moxonidine with hydrochlorothiazide, glibenclamide (glyburide), or digoxin farmakokinetichskoe no interaction.
Tricyclic antidepressants may decrease the effectiveness of antihypertensive drugs central action.
Moksinidin moderately enhances cognitive decline in patients receiving lorazepam.
Appointment testosterone propionate side effects together with benzodiazepines may be accompanied by increased sedative effect of the latter.
It is dampening effect on the central nervous system anxiolytics, barbiturates and ethanol. Beta-blockers increase bradycardia vyrazhennostotritsatelnogo ion and dromotropic action.
In appointing Moxonidine together with moclobemide pharmacodynamic interaction is absent.
If necessary, cancel both received beta-blockers and Moksogammy first cancel beta-blockers, and only a few days, Moksogammu.
Not recommended to prescribe tricyclic antidepressants concurrently with moxonidine.
During treatment requires regular monitoring of blood pressure, heart rate and ECG. Moxonidine can be administered with thiazide diuretics, ACE inhibitors, and blockers “slow” calcium channels. Stop receiving Moksogammy should gradually.
Patients with rare hereditary disorders of galactose intolerance, lack of lactose or malabsorption of glucose-galactose should not take this drug.
Effects on ability to drive the car and to the machines and management mechanisms
There are reports of drowsiness and dizziness during treatment with moxonidine. This should be considered when performing the above operations.
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