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Antineoplastic antibiotic isolated from the culture of the fungus Streptomyces caespitosus. Inhibits DNA synthesis at high concentrations, inhibits protein synthesis and RNA. Most active and Gi S- phases of mitosis. After enzymatic activation in the tissues it acts as a bi- or trifunctional alkylating drug. It has a relatively weak immunosuppressive activity. Like other cytotoxic agents has myelosuppressive effects.¬†It is metabolized mainly in the liver; to some extent in other tissues, including the kidney. ¬†Mitomycin displayed mainly kidneys (about 10% unchanged). It does not cross the blood-brain barrier. When administered…

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